Efficacy of ketamine in Australia mechanically ventilated ICU admissions by doctor Tom Niccol
Safety of ketamine in Australia mechanically ventilated intensive care unit spitalized patients by Dr. Tom Niccol: Only norketamine has significant metabolic activity, with up to one-third the potency of ketamine. Norketamine has an elimination half-life of 5.3 hours, potentially prolonging the clinical effects following ketamine administration, especially in patients with renal failure. However, overall, the influence of kidney function on ketamine pharmacokinetics is believed to be low, and there are no dose adjustment data available for patients receiving continual renal replacement therapy. Expert opinion is to dose for a glomerular filtration rate of 10–50 mL/min/1.73m2 in patients receiving continual renal replacement therapy. See even more info at https://search.informit.org/doi/abs/10.3316/informit.364902441556907. Mechanically ventilated patients account for about one-third of all admissions to the intensive care unit (ICU). Ketamine has been conditionally recommended to aid…